The immune system not only responds to infections and other potentially problematic abnormalities in the body, it also contains a built-in brake in the form of regulatory T cells, or Tregs. Tregs ensure that inflammatory responses don’t get out of hand and do damage. In autoimmune diseases, sometimes these Treg cells don’t act as they should.
Working with yeast and worms, researchers found that incorrect gene expression is a hallmark of aged cells and that reducing such “noise” extends lifespan in these organisms. The team published their findings this month in Genes & Development.
The importance of a diet rich in fish oils – now a billion dollar food-supplement industry -- has been debated for over half a century. A few large clinical trials have supported the idea that fish oils confer therapeutic benefits to patients with cardiovascular disease. Researchers think that hearts and blood vessels may benefit in part from their anti-inflammatory properties.
Sleepy Fruitflies Get Mellow: Sleep Deprivation Reduces Aggression, Mating Behavior in Flies, Penn Study Finds
Whether you're a human, a mouse, or even a fruitfly, losing sleep is a bad thing, leading to physiological effects and behavioral changes. One example that has been studied for many years is a link between sleep loss and aggression. But it can be difficult to distinguish sleep loss effects from stress responses, especially in rodent or human models.
The lymphatic system provides a slow flow of fluid from our organs and tissues into the bloodstream. It returns fluid and proteins that leak from blood vessels, provides passage for immune and inflammatory cells from the tissues to the blood, and hosts key niches for immune cells. How this system develops hasn’t been well understood, but now researchers from the Perelman School of Medicine at the University of Pennsylvania have found from experiments in mice that the early flow of lymph fluid is a critical factor in the development of mature lymphatic vessels.
Physicians in training are twice as likely to order a costly brand-name statin (used to lower blood cholesterol levels) when supervised by senior physicians who prefer those medications in their own practice, according to a new study led by researchers at the
L. Scott Levin of the Perelman School of Medicine discusses leading a team of surgeons to perform the world’s first bilateral hand transplant on a child.
Just as the brain forms memories of familiar faces, the immune system remembers pathogens it has encountered in the past. T cells with these memories circulate in the blood stream looking for sites of new infection.