PHILADELPHIA — Independent clinical trials, including one conducted at the Scheie Eye Institute at the Perelman School of Medicine, have reported safety and efficacy for Leber congenital amaurosis (LCA), a congenital form of blindness caused by mutations in a gene (RPE65) required for recycling vitamin A in the retina. Inherited retinal degenerative diseases were previously considered untreatable and incurable.
PHILADELPHIA — Last year, a team of University of Pennsylvania physicists showed how to undo the “coffee-ring effect,” a commonplace occurrence when drops of liquid with suspended particles dry, leaving a ring-shaped stain at the drop’s edges. Now the team is exploring how those particles stack up as they reach the drop’s edge, and they discovered that different particles make smoother or rougher deposition profiles at the drop edge depending on their shape.
Charles Branas of the Perelman School of Medicine is quoted about the motive behind scientists researching firearms used in self-defense.
While some Ivy League professors are clean-cut academics who wear suits with bowties and carry stacks of books from the library, others shatter that image.
Instead, some wear jeans and explore very dark, far-away places. One of those researchers studies the underworld of the sex trade -- not just in Philadelphia but also in New York City and in India.
Dean Richard Gelles of the School of Social Policy and Practice joins a conversation about the consequences of the federal ban on funding for firearms research.
PHILADELPHIA – Psychiatric disorders are prevalent among current and former inmates of correctional institutions, but what has been less clear is whether incarceration causes these disorders or whether inmates have these problems before they enter prison.
PHILADELPHIA — In the first study to examine discussion of drug side effects on Internet message boards, researchers from the Perelman School of Medicine at the University of Pennsylvania found that breast cancer survivors taking the commonly prescribed adjuvant therapy known as aromatase inhibitors (AIs) often detailed in these forums troublesome symptoms resulting from the drugs, and they were apt to report discontinuing the treatment or switching to a different drug in the same class.
Penn Study: Transmission of Tangles in Alzheimer's Mice Provides More Authentic Model of Tau Pathology
PHILADELPHIA — Brain diseases associated with the misformed protein tau, including Alzheimer’s disease and frontotemporal lobar degeneration with tau pathologies, are characterized by neurofibrillary tangles (NFTs) comprised of pathological tau filaments. Tau tangles are also found in progressive supranuclear palsy, cortical basal degeneration and other related tauopathies, including chronic traumatic encephalopathy due to repetitive traumatic brain injuries sustained in sports or on the battle field.