The human genome encodes roughly 20,000 genes, only a few thousand more than fruit flies. The complexity of the human body, therefore, comes from far more than just the sequence of nucleotides that comprise our DNA, it arises from modifications that occur at the level of gene, RNA and protein.
A scar might be a reminder of an accident or surgery, but the fibrous tissue that makes up a scar also forms after a heart attack and arises in solid tumors as well as in chronic diseases such as liver cirrhosis and muscular dystrophy. Implanted medical devices and materials are similarly surrounded by fibrous capsules that impede their function.
Dealing with the difficulties of family illnesses and financial problems inspired Mary Sun to study medicine and business at the University of Pennsylvania.
Mathias Basner of the Perelman School of Medicine is interviewed about sleep deprivation, the relationship between work and sleep and other topics about the science of sleep.
Remediating Abandoned, Inner City Buildings Reduces Crime and Violence in Surrounding Areas, Penn Study Finds
Fixing up abandoned buildings in the inner city doesn’t just eliminate eyesores, it can also significantly reduce crime and violence, including gun assaults, researchers from the University of Pennsylvania and Penn’s Perelman School of Medicine report in the first study to demonstrate the direct impact of building remediation efforts on crime.
Affordable Care Act Results in Dramatic Drop in Out-of-Pocket Prices for Prescription Contraceptives, Penn Medicine Study Finds
Average out-of-pocket spending for oral contraceptive pills and the intrauterine device (IUD), the two most common forms of contraception for women, has decreased significantly since the Affordable Care Act (ACA) took effect.
Serious Adverse Events Rare in Healthy Volunteers Participating in Phase I Drug Trials, Penn Medicine Study Finds
Many people believe that phase I trials with healthy volunteers are very risky and because they pose risks with no benefits, unethical. But how risky are such trials?
In the first study of its kind, Penn researchers have shown how an anti-diabetic drug can have variable effects depending on small natural differences in DNA sequence between individuals.
Cancer cells defy the rules by which normal cells abide. They can divide without cease, invade distant tissues and consume glucose at abnormal rates.