Perelman School of Medicine

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Penn Researchers Develop an Injectable Gel that Helps Heart Muscle Regenerate after a Heart Attack
November 29, 2017
In mammals, including humans, the cells that contract the heart muscle and enable it to beat do not regenerate after injury. After a heart attack, there is a dramatic loss of these heart muscle cells and those that survive cannot effectively replicate. With fewer of these contractile cells, known as cardiomyocytes, the heart pumps less blood with each beat, leading to the increased mortality associated with heart disease.
Penn Neuroscientists Construct First Whole-brain Map Showing Electrical Connections Key to Forming Memories
November 22, 2017
A team of neuroscientists at the University of Pennsylvania has constructed the first whole-brain map of electrical connectivity in the brain based on data from nearly 300 neurosurgical patients with electrodes implanted directly on the brain. The researchers found that low-frequency rhythms of brain activity, when brain waves move up and down slowly, primarily drive communication between the frontal, temporal and medial temporal lobes, key brain regions that engage during memory processing. 
Four Penn Professors Among 2017 Class of AAAS Fellows
November 20, 2017
Four members of the University of Pennsylvania faculty have been named Fellows of the American Association for the Advancement of Science. Election as an AAAS Fellow is an honor bestowed upon members of AAAS, the world’s largest general scientific society, by their peers.
Penn Researchers Link Binge Eating and Weight-loss Challenges
November 15, 2017
Overweight or obese patients who binge eat while trying to lose weight drop half as much as those who don’t binge eat or those who do and subsequently stop, according to new research from Ariana Chao of the School of Nursing and the School of Medicine and Thomas Wadden of Medicine.
What Can Twitter Reveal About People With ADHD? Penn Researchers Provide Answers
November 8, 2017
People with attention-deficit/hyperactivity disorder tend to tweet using words like “hate” or “disappointed,” messages related to lack of focus, self-regulation, intention and failure and expressions of mental, physical and emotional exhaustion, according to research from Sharath Guntuku, Lyle Ungar, J. Russell Ramsay and Raina Merchant.
First Microscopic Video of Blood Clot Contraction Reveals How Platelets Naturally Form Unobtrusive Clots
November 8, 2017
The first view of the physical mechanism of how a blood clot contracts at the level of individual platelets is giving researchers from the Perelman School of Medicine at the University of Pennsylvania a new look at a natural process that is part of blood clotting. A team led by John W. Weisel, PhD, a professor of Cell and Developmental Biology, describes in Nature Communications how specialized proteins in platelets cause clots to shrink in size.
Paving a New Path to Parenthood: Penn Medicine Launches First Clinical Trial for Uterine Transplant in the Northeast
November 7, 2017
Penn Medicine will conduct the Northeast’s first clinical trial of uterine transplants, to provide women with Uterine Factor Infertility (UFI) - an irreversible form of female infertility that affects as many as 5 percent of women worldwide and 50,000 women in the United States - with a new path to parenthood. A woman with UFI cannot carry a pregnancy either because she was born without a uterus, has had the organ surgically removed, or has a uterus that does not function properly.
Penn Study Pinpoints H3N2 Mutation in Last Year’s Flu Vaccine as Responsible for Lowered Efficacy
November 6, 2017
The low efficacy of last year’s influenza vaccine can be attributed to a mutation in the H3N2 strain of the virus, a new study reports. Due to the mutation, most people receiving the egg-grown vaccine did not have immunity against H3N2 viruses that circulated last year, leaving the vaccine with only about 30 percent effectiveness. Scott Hensley, PhD, an associate professor of Microbiology, in the Perelman School of Medicine at the University of Pennsylvania, describes his team’s findings in the Proceedings of the National Academy of Sciences this week.
Penn Medicine: Blood Flow in the Developing Heart Guides Maturation of Heart Valves
October 26, 2017
Congenital heart valve defects appear in 2 percent of all live births, making them the most common type of birth defect. While some of these defects have been linked to specific genetic mutations, the majority have no clearly definable genetic cause, suggesting that epigenetic factors – changes in gene expression versus an alteration in the genetic code -- play an important role.
Penn Radiology Researcher Awarded $3.9 Million to Help Develop First Three-Dimensional Digital Atlas of Brain Cells
October 23, 2017
James C. Gee, PhD, director of the Penn Image Computing and Science Laboratory in the Department of Radiology at the Perelman School of Medicine at the University of Pennsylvania, has received two grants totaling $3.9 million from the National Institutes of Health to help develop a first-ever three-dimensional, cellular-resolution digital atlas of  brain cell types in collaboration with national colleagues from the Allen Institute for Brain Science, Broad Institute of MIT and Harvard, and University of California, San Diego.