Perelman School of Medicine

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Penn Oral and Maxillofacial Surgeon Driven by Desire to ‘Make Someone Whole Again’
August 29, 2017
When he’s not busy in the clinic, Shanti, who joined Penn’s School of Dental Medicine as an assistant professor last year, is devoting energy in the lab to better understand what drives oral cancers and to design new structures that will more effectively replace the tissues his patients lose during surgery, whether due to cancerous or benign tumors, trauma or inflammatory conditions.
Successful Guide Dogs Have ‘Tough Love’ Moms, Penn Study Finds
August 7, 2017
Much has been written of the pitfalls of being a helicopter parent, one who insulates children from adversity rather than encouraging their independence. A new study from the University of Pennsylvania seems to back up this finding — in dogs. Researchers showed that doting mothers seem to handicap their puppies, in this case reducing the likelihood of successfully completing a training program to become guide dogs.
In New Role at Penn, a GSE Alum and Formerly Homeless Teen, Finds a Way to Support Vulnerable Youth Across Pennsylvania
July 31, 2017
Seth Morones-Ramírez, an alumnus of the University of Pennsylvania’s Graduate School of Education, grew up in and out of the foster-care system. At times, he was homeless: staying in a motel, car, group home or shelter or sleeping on the couches of kind-hearted friends. The hardest part was “surviving it,” says Morones-Ramírez and the lingering sense of fear, loss, abandonment and being unloved. “You don’t ever stop feeling like a homeless kid,” he says. “Academia calls that ‘trauma.’”
Penn Wharton China Center Reflects Upon Two Years of Progress and Growth
July 12, 2017
On launching the Penn Wharton China Center in Beijing, in March of 2015, University of Pennsylvania President Amy Gutmann said, “We are building on Penn's history of broad, deep engagement with China and creating a Center that provides an impressive infrastructure and significant resources to augment Penn's many collaborations and partnerships with great Chinese educational inst
Brain Training Has No Effect on Decision-making or Cognitive Function, Penn Researchers Report
July 10, 2017
During the last decade, commercial brain-training programs have risen in popularity, offering people the hope of improving their cognitive abilities through the routine performance of various “brain games” that tap cognitive functions such as memory, attention and cognitive flexibility. But a recent study at the University of Pennsylvania found that, not only did commercial brain training with Lumosity™ have no effect on decision-making, it also had no effect on cognitive function beyond practice effects on the training tasks.
Penn Researchers Engineer Macrophages to Engulf Cancer Cells in Solid Tumors
July 6, 2017
One reason cancer is so difficult to treat is that it avoids detection by the body. Agents of the immune system are constantly checking the surfaces of cells for chemical signals that say they belong, but cancer cells express the same chemical signals as healthy ones. Without a way for the immune system to tell the difference, little stands in the way of cancer taking over.
A Perturbed Skin Microbiome Can Be ‘Contagious’ and Promote Inflammation, Penn Study Finds
June 29, 2017
Even in healthy individuals, the skin plays host to a menagerie of bacteria, fungi and viruses. Growing scientific evidence suggests that this lively community, collectively known as the skin microbiome, serves an important role in healing, allergies, inflammatory responses and protection from infection.
Six Research Projects at Penn Bolstered Through Quartet Pilot Competition Funding
June 19, 2017
Six faculty members from different schools at the University of Pennsylvania are taking their research one step further, with support from the annual Quartet Pilot Research Project Competition. Designed to attract new and early career investigators and encourage cross-disciplinary aging research, the competition provides support for innovative or exploratory research projects leading to National Institutes of Health grant applications.
Penn Study Details Impact of Antibiotics, Antiseptics on Skin Microbiomes
June 19, 2017
The use of topical antibiotics can dramatically alter communities of bacteria that live on the skin, while the use of antiseptics has a much smaller, less durable impact. The study, conducted in mice in the laboratory of Elizabeth Grice, PhD, an assistant professor of Dermatology in the Perelman School of Medicine at the University of Pennsylvania, is the first to show the long-term effects of antimicrobial drugs on the skin microbiome. Researchers published their findings today in the journal Antimicrobial Agents and Chemotherapy.
Penn/CHOP Team Gains Insights Into Cause of Infant Leukemias and Those Triggered by Chemotherapy
June 14, 2017
Certain pediatric leukemias share a common underlying cause with treatment-related secondary leukemias. Both diseases involve translocations in the KMT2A gene, in which a portion of this gene is swapped out with DNA from a “partner” gene on a separate chromosome. The resulting recombination causes an abnormal genetic rearrangement called a translocation that leads to leukemia, which is cancer of the blood cells. Patients with these types of leukemias tend to have poor outcomes.