Why Everyone You Know Is Doing the Whole30—the Diet Nutritionists Call 'Baseless'

Jacob Riis of the Wharton School says it is “easier to convey anecdotes in the age of social media.”

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Penn Medicine, Geisinger Patients Can Take Health Records With Them on Their iPhones

Michael Restuccia of Penn Medicine comments on how viewing health records on an app could streamline doctor visits, particularly for new patients.

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Video: Best-selling Author Adam Grant: The Most Highly-functional Companies Have These 3 Traits

Adam Grant of the Wharton School is interviewed about his experience visiting the strongest functioning workplaces.

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In Experiments, Researchers Figured Out What Men and Women Really Want in a Mate

Katherine Milkman of the Wharton School writes about what men and women desire in a mate.

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The PhD She Never Knew

Nichole García of the Graduate School of Education writes an essay about pursuing her doctorate and how her grandmother instilled the importance of education in her from a young age.

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The Making of Chinatown's Emerging - Yet Modest - King of Cool

Domenic Vitiello of the School of Design is cited for his 2017 article “Who Owns Chinatown: Neighbourhood Preservation and Change in Boston and Philadelphia.”

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At Penn, Robust Undergraduate Seminar Takes Students to India

Jill DiSanto | jdisanto@upenn.edu | 215-898-4820
Monday, February 12, 2018
Penn Global Seminar in India

Seven students immersed themselves in “The Performing Arts of Modern South India” through a year-long course that included a 12-day visit to India. Photo: Penn Global

Nearly 8,000 miles from the University of Pennsylvania’s campus in Philadelphia, seven students immersed themselves in “The Performing Arts of Modern South India” through a year-long course that included a 12-day visit to India and continues through the spring.

During the fall semester on campus, the students reviewed the development of the performing arts in pre- and post-colonial South India, such as Bharatanāṭyam dance and Karṇāṭak music. In addition, they wrestled with questions surrounding citizenship, caste politics, law, marginalization and disenfranchisement.

The class is a part of an ongoing series of courses called “CU in India,” co-sponsored by the Center for South Asia and the Department of South Asia Studies. While “CU in India” has been in existence for a few years, this is the first time Davesh Soneji, an associate professor in the School of Arts & Sciences who started at Penn in the fall of 2016, is teaching it.

Soneji specializes in the intersections of social and cultural history, religion and anthropology. His work centers on religion and the performing arts in South India, along with gender, class, caste and colonialism.

While some college-level study-abroad programs are generic cultural introductions, Soneji says this Penn Global Seminar takes a different approach.

“We begin with micro-histories about music, dance and theater and dive into larger questions about South Asia's modern history, which includes critical examinations of issues like gender, class and caste, as well as the ‘meta issues’ of modernity and its discontents in this part of the world,” Soneji says. “The course uses the performing arts to talk about issues related to social justice, religion and contemporary politics.”

More important, the class explored the ways in which these art forms were essentially appropriated from socially marginalized populations who were prevented from embracing their cultural heritage as a result of social-reform movements.

Penn Global Seminar in India 3

Photo: Penn Global

Curtis Kuo, a senior biochemistry and biophysics major in the School of Arts and Sciences from East Lansing, Mich., says the most jarring thing he has learned so far in the course had to do with this sort of cultural hijacking.

“In the reinvention of classical traditions, the government and upper-class elites have taken groups' means of livelihood and cast them aside, while marketing the art forms as ‘pure and ancient Indian dance, musi, or theater,’” Kuo says, adding that last semester was heavy on reading and lectures to prepare the students for when they actually arrived in India.

The cohort traveled from Dec. 22 to Jan. 2, visiting towns and villages in South India. This short-term overseas-travel component contextualized the content, allowing for an in-depth understanding of classroom concepts.

“Part of the course,” Soneji says, “involved visiting historical sites related to the production of music and dance in the 19th century but also involved speaking to artists from disenfranchised communities about their experiences in the modern world of India's arts.”

Tara Giangrande from Frederick, Md., is taking classes through the post-baccalaureate studies program at Penn’s College of Liberal and Professional Studies to expand the breadth of her academic coursework to ready herself for graduate study.

By traveling to India, Giangrande says everything that the students talked about in the classroom turned into “a real, tangible experience of how hereditary performance communities have been impacted by elite cultural agendas.”

Penn Global Seminar in India 2

Photo: Penn Global

For another student enrolled in the course, Courtney Daub, a freshman from Milton, Pa., the trip made her want to visit again in the future but stay for a much longer amount of time.

“It was really focused on engagement with people and learning about their expertise and experiences within the context of what we'd been learning in the course,” Daub says. “A lot of what is appealing to me within cultural anthropology is this engagement with people and an emphasis on the histories that inform the present, mixing academic and activist work.”

Most costs are covered through the Hasan and Arifa Ahmad Fund, Penn Global and Penn’s Global Engagement Fund.

Through unique opportunities like Penn Global Seminars, Soneji says, he is able to share his work in a niche setting while students were able to connect firsthand with highly specialized research that grapples with “big questions” in the field of South Asian studies.

“Students were able to see how the historical issues we examined have deep and long-lasting consequences for real people even up to the present moment,” he says.

For the rest of the current semester, the students will be completing independent research projects that will culminate in a final 30-page paper.

At first, Kuo was hesitant to sign up for the course because of the year-long commitment, but he’s glad that he did.

“The ‘CU in India’ program is for students who are otherwise too busy to fit a semester or summer abroad. It’s tough for biochemistry majors to take a semester abroad, so this was perfect for me,” Kuo says. “It’s a great way to spend my final year at Penn.”

For photos from this Penn Global Seminar, click here.

Penn Global Seminar in India 4

Photo: Penn Global

Penn Chemists Develop Motion Capture-like Technology for Tracking Protein Shape

Ali Sundermier | alisun@upenn.edu | 215-898-8562
Monday, February 12, 2018
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In many modern animated movies, the trick to achieving realistic movements for individual characters and objects lies in motion-capture technology. This process often involves someone wearing a tracking suit covered in small, colored balls while a camera captures the position of those colored balls, which is then used to represent how the person is moving.

Researchers at the University of Pennsylvania are developing a similar technology to obtain atomic-resolution “movies” that track how proteins fold and change shape. To generate these movies, the scientists label the protein with probes at many positions and observe the movement of those labels. The fluorescence data on the relative positions of the probes can then be used to construct computational models of the protein structure in atomic detail. This research could lead to improvements in drugs used to treat neurodegenerative diseases, as well as new methods of imaging that could lead to their earlier detection.

The research was multi-disciplinary effort led by E. James Petersson, associate professor of chemistry in Penn’s School of Arts and Sciences, and graduate student Jack Ferrie. Elizabeth Rhoades and Zahra Fakhraii, both associate professors of chemistry at Penn, as well as Abhinav Nath of the University of Washington, Seattle; Penn undergraduate Jimin Yoon; postdoctoral fellow Conor Haney; and graduate students Buyan Pan and Yi-Chih Lin also contributed to the study. The paper was published in Biophysical Journal.

“One of the big fundamental questions in biochemistry is how proteins fold into a certain shape,” said Petersson, “and this is dictated by the sequence of amino acids in the protein. The information in all of the interactions of the amino acid side chains somehow leads to it folding into a proper shape.”

In healthy scenarios, Petersson said, that proper shape allows the protein to have different functions, such as transporting oxygen in the blood or becoming “molecular machines” that ultimately lead to muscle movements, such as those required for walking and running.

But in certain disease states, particularly in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, the proteins misfold into an unhealthy shape, which can cause multiple copies of the proteins to aggregate into “spaghetti-like tangles or long fibrils.” These fibrils, Petersson said, are toxic to neurons, which underlies Alzheimer’s and Parkinson’s disease.

“Since all of these involve protein folding into a certain shape, then what we'd like to do is to track the changes in shape of proteins,” he said. “There are a number of different techniques that can be used to do this, but we like fluorescence because you can acquire fluorescence data fast enough that you can actually watch proteins fold in real time. Ultimately we'd like to try to watch proteins folding in cells.”

To get information about protein shape using fluorescent probes, researchers use a technique called fluorescence resonance energy transfer, which requires them to measure many distances between different points on the protein and then use that information to understand its shape, similar to motion-capture technology.

In this paper, the researchers made about 30 measurements of different distances within the protein alpha-synuclein under different states where it's changing shape. They then used that collection of distance measurements in combination with complex computational modeling to get atomic resolution structures of the protein’s shape.

Ferrie received a fellowship from the Parkinson’s Disease Foundation to spend the summer in David Baker’s laboratory in the University of Washington, where Rosetta, one of the most commonly used programs for modeling proteins, was developed.

“Rosetta is designed to model stable well-folded proteins,” Petersson said, “not disordered proteins that can change shape, so Jack had to do a lot of rewriting of the code himself to be able to model these unruly proteins.”

Ferrie and Yoon made a series of experimental measurements that could be used to direct the protein folding to be consistent with the experimental measurements, which allowed him to model protein shape.

Since it was a new approach, the researchers wanted to demonstrate that the structures coming out of the computational models were consistent with reality. In order to do this, they conducted three types of experiments to match real data with the models coming out of these fluorescence experiments.

They collaborated with Rhoades’ group to validate the modeled structures using single molecule fluorescence measurements made by Pan. Working in Fakhraii’s group, Lin, used a different type of technique called atomic force microscopy to image the protein and validate the models. Chris Dobson, a professor of chemistry at Cambridge University, shared nuclear magnetic resonance data about alpha-synuclein that provided further confirmation of the accuracy of the computer models.

The paper represents one of the largest libraries of proteins labeled with synthetic fluorophores yet reported. According to Petersson, the researchers needed to make a lot of distance measurements over different regions of the protein to have enough data to generate computational models. Ferrie and Haney had to come up with a streamlined approach to attaching different sets of probes that would function over different distance ranges.

The researchers are now working to apply this technique to model protein structure in the aggregated forms that are toxic to neurons and to model its response to drugs that would cause it to change shape, preventing this aggregation.

“The ability to watch a protein as it changes shape,” said Petersson, “and to actually get structures out of that is a really important basic science goal that we've been working towards for 10 years. There have been some very impressive breakthroughs in getting structures of proteins in neurodegenerative diseases, but the fluorescence technique has the potential to do that in living cells, which no other technique has the ability to do.”

According to Petersson, proteins adopting multiple shapes, stacking different copies upon each other and aggregating, as they do in neurodegenerative diseases, are an important basic biochemistry problem that other structural biology techniques can’t really tackle. A better understanding of how that works and what those shapes are has the potential to make an impact on diseases such as Parkinson’s and to give researchers an opportunity to figure out how drug or diagnostic models interact with the protein.

“We're working on being able to generate model structures that actually show what is the effect of these drugs,” Petersson said. “We take the protein with the fluorescent labels, add the drug, allow the protein to change shape, make fluorescence measurements and then take those back to the computational modeling so we can actually see the structural effect of these drugs. Hopefully this will lead to more of a rational understanding so that better second and third generation drugs can be made.”

The researchers are also collaborating with Robert Mach, the Britton Chance Professor of Radiology in Penn’s Perelman School of Medicine. Mach’s group is interested in developing positron emission tomography imaging probes that can be used to bind to the aggregated forms of proteins and image them in patients.

“There are some promising drugs for treating neurodegenerative diseases such as Alzheimer’s and Parkinson’s, that could block this formation of aggregates,” Petersson said, “but the problem is that, by the time people show cognitive or motor-tremor symptoms, it's too late to use these drugs because there's already too much neurodegeneration. If you're getting aggregates in your brain, even if you're not showing any behavioral changes or learning deficits, these probes could noninvasively image the aggregates. By achieving a rational understanding of what the protein structure is, we hope we can help with that work moving forward.”

This research was supported by the University of Pennsylvania, the National Institutes of Health (grants NS081033 and NS079955), the Alfred P. Sloan Foundation, the National Science Foundation (DGE-1321851), an Age Related Neurodegenerative Disease training grant (NIH T32 AG000255) and the University of Pennsylvania Center for Undergraduate Research and Fellowships.

University Mourns Loss of Aran Rana

Dr. Valarie Swain-Cade McCoullum, Vice Provost for University Life

on behalf of President Amy Gutmann and Provost Vincent Price

March 1, 2017



I am so very sad to share the news of the passing of your classmate, Aran Rana, who died Monday at home in Hong Kong. Aran was 19 and on a leave of absence from the university.

Our Digital Devices May Be Revealing More About Us Than We Realize

Joseph Turow of the Annenberg School for Communication comments on how digital assistant devices such as Amazon Echo and Google Home collect data and how it is used.

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