Dean of Penn’s Perelman School of Medicine: Precision Medicine is “Personalized, Problematic, and Promising”

The rapidly emerging field of precision medicine is a “disruptive innovation” that offers the possibility of remarkably fine-tuned remedies to improve patient health while minimizing the risk of harmful side effects, says J. Larry Jameson, MD, PhD, dean of the Perelman School of Medicine and executive vice president of the University of Pennsylvania for the Health System, in this week’s issue of the New England Journal of Medicine. Writing with oncologist Dan L. Longo, MD, a professor of Medicine at Harvard Medical School,in a “Sounding Board” piece, Jameson surveys the terrain of the new field.

Precision medicine, they write, raises the potential of a “daunting explosion of information and the associated clinical guidelines.” Moreover it creates a set of conditions where the interests of patients, physicians, health systems, insurance companies, government agencies, and the pharmaceutical industry may not fully coincide, setting the stage for an absence of consensus on appropriate care choices. 

The authors define precision medicine as “treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations.” Buttressing this definition “is the goal of … minimizing unnecessary side effects.” 

Noting that “many physicians contend that they have always practiced individualized and personalized medicine,” the authors distinguish this new field by the rapid pace of advances in diagnostic and treatment options powered by the convergence of technological breakthroughs. These include DNA sequencing (to identify genetic precursors to diseases for early treatment), cell sorting (isolating different cell types for study and treatment), epigenetics (externally turning genes "on" or "off"), proteomics (analyzing and identifying protein structure and function), and metabolomics (measuring and analyzing sugars and fats to improve diagnosis and treatment). In addition, sophisticated imaging such as computed tomography and ultrasonography can lead to highly accurate diagnoses, sparing patients from invasive testing or exploratory surgery.

Jameson and Longo point out that electronic health records also are an important factor in personalized medicine, and will grow in importance. Capitalizing on rich databases of clinical information, algorithms have been developed to identify patients at risk for certain diseases and to recommend drug selection and administration.

Such advances, however, must be weighed against the risk of information overload. For example, medicine has a history of dividing practitioners and researchers into “lumpers,” who group related conditions together, and “splitters,” who apply more exact definitions and thereby define more discrete entities. The authors say that advances in genetics and biomarkers will shift this balance in favor of the splitters. While this raises the prospect of more precise diagnosis and treatment, it complicates these processes, as well. In particular, primary care providers may have the most challenging role in precision medicine. Referrals to specialists will likely increase as a result.

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