Displaying 21 - 30 of 876 articles
What Can Twitter Reveal About People With ADHD? Penn Researchers Provide Answers
November 8, 2017
People with attention-deficit/hyperactivity disorder tend to tweet using words like “hate” or “disappointed,” messages related to lack of focus, self-regulation, intention and failure and expressions of mental, physical and emotional exhaustion, according to research from Sharath Guntuku, Lyle Ungar, J. Russell Ramsay and Raina Merchant.
First Microscopic Video of Blood Clot Contraction Reveals How Platelets Naturally Form Unobtrusive Clots
November 8, 2017
The first view of the physical mechanism of how a blood clot contracts at the level of individual platelets is giving researchers from the Perelman School of Medicine at the University of Pennsylvania a new look at a natural process that is part of blood clotting. A team led by John W. Weisel, PhD, a professor of Cell and Developmental Biology, describes in Nature Communications how specialized proteins in platelets cause clots to shrink in size.
Paving a New Path to Parenthood: Penn Medicine Launches First Clinical Trial for Uterine Transplant in the Northeast
November 7, 2017
Penn Medicine will conduct the Northeast’s first clinical trial of uterine transplants, to provide women with Uterine Factor Infertility (UFI) - an irreversible form of female infertility that affects as many as 5 percent of women worldwide and 50,000 women in the United States - with a new path to parenthood. A woman with UFI cannot carry a pregnancy either because she was born without a uterus, has had the organ surgically removed, or has a uterus that does not function properly.
Penn Study Pinpoints H3N2 Mutation in Last Year’s Flu Vaccine as Responsible for Lowered Efficacy
November 6, 2017
The low efficacy of last year’s influenza vaccine can be attributed to a mutation in the H3N2 strain of the virus, a new study reports. Due to the mutation, most people receiving the egg-grown vaccine did not have immunity against H3N2 viruses that circulated last year, leaving the vaccine with only about 30 percent effectiveness. Scott Hensley, PhD, an associate professor of Microbiology, in the Perelman School of Medicine at the University of Pennsylvania, describes his team’s findings in the Proceedings of the National Academy of Sciences this week.
Penn Biologists Show How Chromosomes ‘Cheat’ for the Chance to Get Into an Egg
November 2, 2017
Each of your cells contains two copies of 23 chromosomes, one inherited from your father and one from your mother. Theoretically, when you create a gamete — a sperm or an egg —  each copy has a 50-50 shot at being passed on. But the reality isn’t so clearcut.
Penn’s Restoring Active Memory Project Adds Task and Patient Data to Publicly Available Human Brain Dataset
November 1, 2017
When the Restoring Active Memory program published its human intracranial brain recording and stimulation data in 2016, it was the largest publicly available dataset of its kind. The Penn project has now added to that store, releasing data for 102 more patients and for a new spatial navigation task developed by researchers at Columbia.
Targeting Enzyme in ‘Normal’ Cells May Impede Pancreatic Cancer’s Spread, Penn Vet Team Shows
October 27, 2017
Cancer of the pancreas is a deadly disease, with a median survival time of less than six months. Only one in 20 people with pancreatic cancer survives five years past the diagnosis. The reason is the cancer’s insidiousness; tumor cells hide deep inside the body, betraying no symptoms until late in the disease, when the cancer has almost invariably spread to other organs.
Penn Medicine: Blood Flow in the Developing Heart Guides Maturation of Heart Valves
October 26, 2017
Congenital heart valve defects appear in 2 percent of all live births, making them the most common type of birth defect. While some of these defects have been linked to specific genetic mutations, the majority have no clearly definable genetic cause, suggesting that epigenetic factors – changes in gene expression versus an alteration in the genetic code -- play an important role.
Penn Radiology Researcher Awarded $3.9 Million to Help Develop First Three-Dimensional Digital Atlas of Brain Cells
October 23, 2017
James C. Gee, PhD, director of the Penn Image Computing and Science Laboratory in the Department of Radiology at the Perelman School of Medicine at the University of Pennsylvania, has received two grants totaling $3.9 million from the National Institutes of Health to help develop a first-ever three-dimensional, cellular-resolution digital atlas of  brain cell types in collaboration with national colleagues from the Allen Institute for Brain Science, Broad Institute of MIT and Harvard, and University of California, San Diego.
Penn Study Links Mutations in Notch Gene to Role in B Cell Cancers
October 23, 2017
Notch is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL), the most common leukemia in adults in the United States. It is also often mutated in other common B cell tumors, such as mantle cell lymphoma. However, the role of Notch in these cancers has been uncertain. Now, a collaborative effort between investigators at the Perelman School of Medicine at the University of Pennsylvania and the Harvard Medical School provides new insights into how Notch drives the growth of B-cell cancers. The teams report their findings in Cell Reports.